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More to My Story offers PAH education and support about the topics that may interest you. Explore More to My Story and learn more about PAH and treatment with Letairis.

How Letairis® (ambrisentan) can help

How Letairis
can help

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Financial assistance for Letairis® (ambrisentan)

Financial assistance for Letairis

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What to expect while taking Letairis® (ambrisentan)

What to expect while taking Letairis

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Letairis® (ambrisentan) side effects

Letairis possible side effects

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Letairis® (ambrisentan) REMS program

Letairis REMS program

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What is Letairis?

Letairis is a prescription medicine to treat pulmonary arterial hypertension (PAH) (WHO Group 1) in patients with WHO Class II or III symptoms. PAH is high blood pressure in the arteries of the lungs. Letairis can improve your ability to exercise, and it can help slow down the worsening of your physical condition and symptoms.

Letairis® (ambrisentan) side effects

Letairis patient brochure

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Letairis® (ambrisentan) support programs

Letairis support programs

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Important Safety Information

What is the most important information I should know about Letairis?

Letairis can cause serious birth defects if taken during pregnancy.

  • Females must not be pregnant when they start taking Letairis or become pregnant while taking Letairis.
  • Females who are able to get pregnant must have a negative pregnancy test before beginning Letairis, each month during treatment, and one month after stopping Letairis. Your doctor will decide when to do the tests, and order the tests for you depending on your menstrual cycle.
    • Females who are able to get pregnant are women who:
      • Have entered puberty (even if they have not started their period), and have a uterus, and have not gone through menopause (have not had a period for at least 12 months for natural reasons, or who have had their ovaries removed)

Females who are able to get pregnant must use two acceptable forms of birth control, while taking Letairis and for one month after stopping Letairis because the medication may still be in the body.

  • If you have had a tubal sterilization or have an IUD or progesterone implant, these methods can be used alone and no other form of birth control is needed.
  • Talk with your doctor or gynecologist to find out about options for acceptable forms of birth control that you may use to prevent pregnancy during treatment with Letairis.
  • If you decide that you want to change the form of birth control, talk with your doctor to be sure that you choose another acceptable form of birth control.
  • Do not have unprotected sex. Talk to your doctor or pharmacist right away if you have unprotected sex or if you think your birth control has failed. Your doctor may tell you to use emergency birth control.
  • Tell your doctor right away if you miss a menstrual period or think you may be pregnant.

If you are the parent or caregiver of a female child who started taking Letairis before reaching puberty, you should check your child regularly to see if she is developing signs of puberty. Tell your doctor right away if you notice that she is developing breast buds or any pubic hair. Your child may reach puberty before having her first menstrual period.

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Important Safety Information

What is the most important information I should know about Letairis?

Letairis can cause serious birth defects if taken during pregnancy.

Females who are able to get pregnant must use two acceptable forms of birth control, while taking Letairis and for one month after stopping Letairis because the medication may still be in the body.

If you are the parent or caregiver of a female child who started taking Letairis before reaching puberty, you should check your child regularly to see if she is developing signs of puberty. Tell your doctor right away if you notice that she is developing breast buds or any pubic hair. Your child may reach puberty before having her first menstrual period.

Who should not take Letairis?

Do not take Letairis if:

Tell your doctor about all your medical conditions and all the medicines you take including prescription and nonprescription medicines. Letairis and other medicines may affect each other causing side effects. Do not start any new medicines until you check with your doctor.

Especially tell your doctor if you take the medicine cyclosporine (Gengraf, Neoral, Sandimmune). Your doctor may need to change your dose of Letairis. Do not take more than 5 mg of Letairis per day while taking cyclosporine.

How should I take Letairis?

What should I avoid while taking Letairis?

What are the possible side effects of Letairis?

Serious side effects of Letairis include:

The most common side effects of Letairis are:

Some medicines that are like Letairis can cause liver problems. Tell your doctor if you get any of these symptoms of a liver problem while taking Letairis:

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of Letairis. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep Letairis and all medicines out of the reach of children.

For more information, call 1-866-664-5327 or visit www.letairis.com or www.gilead.com.

What is Letairis?

Letairis is a prescription medicine to treat pulmonary arterial hypertension (PAH) (WHO Group 1) in patients with WHO Class II or III symptoms. PAH is high blood pressure in the arteries of the lungs. Letairis can improve your ability to exercise, and it can help slow down the worsening of your physical condition and symptoms.

Please see full Prescribing Information, including Medication Guide, with important warnings.

The information on this site is intended for residents of the United States who are 18 years of age or older. The content on this site may not apply to non-U.S. audiences as regulatory control, legal requirements and/or medical practices may vary in other countries. The content of this site is protected under applicable copyright and trademark laws. This site may contain, from time to time, information related to various health, medical and fitness conditions, and their treatment. Such information is not meant to be a substitute for the advice provided by a physician or other medical professional. You should not use the information contained herein for diagnosing a health or fitness problem or disease. You should always consult a physician and/or a healthcare provider.

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