Letairis® (ambrisentan) patient

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Important Safety Information

What is the most important information I should know about Letairis?

Letairis can cause serious birth defects if taken during pregnancy.

Females who are able to get pregnant must use two acceptable forms of birth control, while taking Letairis and for one month after stopping Letairis because the medication may still be in the body.

If you are the parent or caregiver of a female child who started taking Letairis before reaching puberty, you should check your child regularly to see if she is developing signs of puberty. Tell your doctor right away if you notice that she is developing breast buds or any pubic hair. Your child may reach puberty before having her first menstrual period.

Who should not take Letairis?

Do not take Letairis if:

Tell your doctor about all your medical conditions and all the medicines you take including prescription and nonprescription medicines. Letairis and other medicines may affect each other causing side effects. Do not start any new medicines until you check with your doctor.

Especially tell your doctor if you take the medicine cyclosporine (Gengraf, Neoral, Sandimmune). Your doctor may need to change your dose of Letairis. Do not take more than 5 mg of Letairis per day while taking cyclosporine.

How should I take Letairis?

What should I avoid while taking Letairis?

What are the possible side effects of Letairis?

Serious side effects of Letairis include:

The most common side effects of Letairis are:

Some medicines that are like Letairis can cause liver problems. Tell your doctor if you get any of these symptoms of a liver problem while taking Letairis:

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of Letairis. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep Letairis and all medicines out of the reach of children.

For more information, call 1-866-664-5327 or visit www.letairis.com or www.gilead.com.

What is Letairis?

Letairis is a prescription medicine to treat pulmonary arterial hypertension (PAH) (WHO Group 1) in patients with WHO Class II or III symptoms. PAH is high blood pressure in the arteries of the lungs. Letairis can improve your ability to exercise, and it can help slow down the worsening of your physical condition and symptoms.

Please see full Prescribing Information, including Medication Guide, with important warnings.

The information on this site is intended for residents of the United States who are 18 years of age or older. The content on this site may not apply to non-U.S. audiences as regulatory control, legal requirements and/or medical practices may vary in other countries. The content of this site is protected under applicable copyright and trademark laws. This site may contain, from time to time, information related to various health, medical and fitness conditions, and their treatment. Such information is not meant to be a substitute for the advice provided by a physician or other medical professional. You should not use the information contained herein for diagnosing a health or fitness problem or disease. You should always consult a physician and/or a healthcare provider.

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